Study: Tandem Mass Spectrometry Method for Analysis of 102 Pesticides and Five Mycotoxins Regulated by the State of Colorado in Dried Hemp
A novel liquid chromatography–tandem mass spectrometry (LC–MS/MS) method with a dual electrospray ionization (ESI) and atmospheric pressure chemical ionization (APCI) source was developed for analyzing 102 pesticides and five mycotoxins that are regulated by the state of Colorado in hemp.
Our sister publication, LGGC, posted a recent study from Avinash Dalmia, Senior Principal Application Scientist with PerkinElmer. In this study, 88 out of 102 pesticides and all five mycotoxins were analyzed using LC–MS/MS with an ESI source, whereas the remaining 14 pesticides were determined using LC–MS/MS with an APCI source. A simple, fast, green, and cheap acetonitrile solvent extraction method was used to extract the pesticides and mycotoxins from the hemp matrix with good extraction efficiency in the range of 80–120%. A hemp matrix is challenging and causes matrix effects such as ion suppression or enhancement. We optimized the LC method and added 30 internal standards to reduce and compensate for these matrix effects to obtain method accuracy in the range of 70–120%. The ionization mechanism of nonpolar pesticides (normally analyzed by gas chromatography–tandem mass spectrometry [GC–MS/MS]) with an APCI ion source was elucidated.
See the full article here.
Best of the Week: July 4 – July 10, 2025
July 11th 2025Here, we bring you our top five recent articles covering revoking medical cannabis cards in Florida, testing and sampling initiative in Missouri, our mid-year regulations roundup, depenalization ordinance stopped in Texas, and accuracy in THC labeling in flower versus concentrates.
Best of the Week: June 27 – July 03, 2025
July 4th 2025Here, we bring you our top five recent articles covering cannabis on state-tribal cannabis regulations in Montana, our podcast discussion on cannabis cultivation, our blog on compliance with federal regulations, public commentary on new standards, and hemp packaging enforcement in Florida.
