is a Senior Scientist at Agilent Technologies and a Visiting Professor at The Johns Hopkins University School of Medicine in Baltimore, Maryland.

Anthony Macherone

Articles

An explanation of the parameters for the implementation of the new methods for the analysis of residual solvents and terpenes using a single gas chromatography–mass spectrometry (GC–MS) system.

Fast Residual Solvents and Terpenes Analyses  in Cannabis and Hemp Products

Experts within the global cannabis and hemp industries discuss the importance of testing and regulations and sustainable measures that can reduce the sector’s environmental impact.

How Manufacturing, Regulations, and Sustainability Are Affecting the Cannabis and Hemp-Based Products Industry

This article focuses on the use of GC–MS for the analysis of derivatized cannabinoids in hempseed oil matrix.

A Brief Review of Derivatization Chemistries for the Analysis of Cannabinoids Using GC–MS

is an Application Scientists with Agilent Technologies in Wilmington, Delaware.

This study highlights a potential concern for the quantitation of acid phytocannabinoids.

The Stability of Acid Phytocannabinoids Using Electrospray Ionization LC–MS in Positive and Negative Modes

In this study, six different brands of CBD oil pet supplements were obtained and untargeted analyses using gas phase-time of flight mass spectrometry were performed.

GC-TOF Discovery-Based Profiling of CBD Oil Pet Supplements 

A study using LC-qTOF, GCqTOF, and GC–MS/MS to evaluate the selectivity of a model pesticide commonly found in regulatory target lists.

Up in Smoke: The Naked Truth for LC–MS/MS and GC–MS/MS Technologies for the Analysis of Certain Pesticides in Cannabis Flower

This review introduces a quantitative polymerase chain reaction (qPCR) assay and compares its performance to culture-based methods.

Optimized Cannabis Microbial Testing: Combined Use of Extraction Methods and Pathogen Detection Tests Using Quantitative  Polymerase Chain Reaction

A Comprehensive Approach to Pesticide Residue Analysis in Cannabis

is Laboratory Director of CWC Labs in Austin, Texas.

is a QC Manager at CWC Labs in Austin, Texas.

A primary impediment to cannabinoid research is the fact that materials possessing psychoactive Δ9-tetrahydrocannabinol (THC) are considered Schedule I drugs as defined in the U.S. Controlled Substances Act. An alternative source of cannabinoids may be found in hemp oil extracts. Hemp contains a low percentage of THC by weight but relatively high amounts of nonpsychoactive cannabinoids. The liquid chromatography–time-of-flight mass spectrometry (LC–TOF-MS) method presented herein allows for the accurate, precise, and robust speciation, profiling, and quantification of cannabinoids in hemp oil extracts and commercial cannabinoid products for research and development laboratories. The method was determined to chromatographically separate 11 cannabinoids including differentiation of Δ8-tetrahdrocannabinol and THC with excellent linear dynamic range, specificity, and sensitivity.