New Review Highlights CBD’s Potential in Skin, Wound Healing, and Oral Health

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A recently published review provided an updated examination of the multiple applications of cannabidiol (CBD) for a variety of skin conditions (1). Through its interactions with the CB1 and CB2 receptors in the skin’s endocannabinoid system, CBD has been shown to have multiple functions and properties including anti-inflammatory, antioxidant, and antibacterial properties, the study explains. Previous studies have provided evidence for its effect in skin conditions from acne to alopecia to cancer. There also exist challenges to the use of CBD, and the need for more data on long-term effects. The current bibliographic review, “Cannabidiol in Skin Health: A Comprehensive Review of Topical Applications in Dermatology and Cosmetic Science,” was published in Biomolecules in August 2025.

CBD and Skin Health: Anti-Inflammatory, Antioxidant, and Antimicrobial Effects

For this review, the researchers analyzed literature from several databases related to CBD and skin conditions, plus topical applications. They noted that imbalances in the skin’s endocannabinoid system (ECS) can contribute to skin conditions and breakdown of the skin barrier function, explaining that CBD interacts with and modulates the ECS, though the exact mechanisms are not fully understood.

Multiple studied were referenced and summarized when demonstrating the effects of CBD for managing: anti-inflammatory, antioxidant, antimicrobial, lipostatic (regulate lipid function), and wound-healing properties.

CBD Delivery Challenges: Improving Absorption for Skincare Benefits

Topical and transdermal applications of CBD are most common in order to achieve high concentrations at a local effect with minimal systemic side effects. However, CBD usually does not reach deep layers of the skin is and is not very water soluble. The researchers suggest new delivery systems for enhanced therapeutic potential and consistent results.

CBD in Dermatology, Cosmetics, and Oral Healthcare

The review examined various studies and trials regarding CBD and skin disorders. With skin cancer, CBD has been shown to interact with the ECS and with additional receptors to reduce cell proliferation, stimulate apoptosis, and suppress tumor angiogenesis.

The review examined studies for various skin disorders that responded to CBD including:

• acne
• allergic contact dermatitis, seborrheic dermatitis, atopic dermatitis
• alopecia
• calciphylaxis (a condition characterized by skin necrosis from vascular calcification)
• epidermolysis bullosa
• pruritus (itching)
• psoriasis and scalp psoriasis
• pyoderma gangrenosum (deep ulcers)

It also summarized CBD and wound healing, both acute and chronic. The cannabinoid’s antioxidant and anti-inflammatory properties were noted for their effect on controlling immune responses, cytokine activity, and reducing oxidative stress.

Though the research is limited, the potential of CBD for antiaging and rejuvenation effects on the skin was also examined, noting the modulating effects on biomarkers. The evolving regulatory landscape and affecting the use of CBD more rigorous safety testing should be further considered, the researchers stated.

CBD use in dentistry was noted for opportunities for dental pulp repair, pain management, and infection control, though challenges such as dosing, mechanisms of action, and other research gaps were also described.

The Future of CBD Applications

Ultimately, though current studies show the potential for CBD to be beneficial in therapeutic uses, its use in dermatology, cosmetics, and other applications is still limited by skin permeability challenges, varied formulations in products, regulatory frameworks, and safety concerns, though its use seems to be well tolerated in the short term. “With continued innovation and scientific validation, CBD may become a valuable and well-integrated active ingredient in dermatological and cosmetic therapies, as well as in emerging applications within oral health care,” the researchers concluded.

Reference

1. Rusu, A.; Farcaș, A-M.; Oancea, O.L.; Tanase, C. Cannabidiol in Skin Health: A Comprehensive Review of Topical Applications in Dermatology and Cosmetic Science. Biomolecules 2025, 15(9), 1219. DOI: 10.3390/biom15091219